They will have a free vote on the technique, which is aimed at preventing deadly genetic diseases being passed from mother to child.
After these vote the UK could become the first country to introduce laws to allow the creation of babies from three people.
It has sparked fierce ethical debate and senior Church figures have called for the procedure to be blocked.
However, if there is a "yes" vote in the Commons, then the first three-person baby could be born as soon as next year. It could eventually help about 150 couples a year.
The technique, which was developed in Newcastle.
Now the question is, who is the baby's father?
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